Brg1 Wt Brg1 Mutant

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(71) Applicants:Zainab JAGANI, Cambridge, MA (US); EPE" application No. 61/846,178, s s s Jul 15, 2013. Gregory HOFFMAN, Cambridge, MA ed. On Jul. 1, (US); Frank Peter STEGMEIER, Publication Classification Cambridge, MA (US); Craig Stephen MICKANIN, Cambridge, MA (US) (51) Int. Cl. CI2O I/68 (2006.01) (72) Inventors: Zainab JAGANI, Cambridge, MA (US); GOIN33/574 (2006.01) Gregory HOFFMAN, Cambridge, MA CI2N IS/II3 (2006.01) (US); Frank Peter STEGMEIER, (52) U.S. Cl. Cambridge, MA (US); Craig Stephen CPC .......... CI2O 1/6886 (2013.01); C12N 15/1137 MICKANIN, Cambridge, MA (US) (2013.01); G0IN33/57496 (2013.01); C12O s s 2600/156 (2013.01); C12O 2600/106 (2013.01); CI2O 2600/158 (2013.01); G0IN 2333/914 (2013.01); C12N 2320/30 (2013.01); C12N (73) Assignee: Novartis AG, Basel (CH) 2310/531 (2013.01); C12N 2310/14 (2013.01)

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Casein kinase 2-mediated phosphorylation of Brahma-related gene 1 controls myoblast proliferation and contributes to SWI/SNF complex composition

Transcriptional regulation is modulated in part by chromatin-remodeling enzymes that control gene accessibility by altering chromatin compaction or nucleosome positioning. Brahma-related gene 1 (Brg1), a catalytic subunit of the mammalian SWI/SNF chromatin-remodeling enzymes, is required for both myoblast proliferation and differentiation, and the control of Brg1 phosphorylation by calcineurin,...

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Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling.

Brg1, a core subunit of the SWI/SNF chromatin remodeling complex, is essential for development and homeostasis of various organs. However, the functional role of Brg1 in intestinal development and homeostasis, and the underlying molecular mechanism, remain unknown. We found that deletion of Brg1 in the mouse intestine resulted in growth impairment and early death associated with abnormal crypt-...

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The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development.

ATP-dependent chromatin-remodeling complexes contribute to the proper temporal and spatial patterns of gene expression in mammalian embryos and therefore play important roles in a number of developmental processes. SWI/SNF-like chromatin-remodeling complexes use one of two different ATPases as their catalytic subunit: brahma (BRM, also known as SMARCA2) and brahma-related gene 1 (BRG1, also kno...

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The BRG1 chromatin remodeler regulates widespread changes in gene expression and cell proliferation during B cell activation.

Widespread changes in gene expression underlie B cell development and activation, yet our knowledge of which chromatin-remodeling factors are essential is limited. Here, we demonstrate that the BRG1 catalytic subunit of SWI/SNF complexes was dispensable for murine B cell development but played an important, albeit selective, role during activation. Although BRG1 was dispensable for CD69 inducti...

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Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart.

RATIONALE Mating type switching/sucrose non-fermenting (SWI/SNF) chromatin-remodeling complexes utilize either BRG1 or BRM as a catalytic subunit to alter nucleosome position and regulate gene expression. BRG1 is required for vascular endothelial cell (VEC) development and embryonic survival, whereas BRM is dispensable. OBJECTIVE To circumvent embryonic lethality and study Brg1 function in ad...

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A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development.

The Brg1 catalytic subunit of SWI/SNF-related complexes has been implicated in many developmental and physiological processes, but null homozygotes die as blastocysts prior to implantation. To circumvent this early embryonic lethality, we performed an ENU mutagenesis screen and generated a Brg1 hypomorph mutation in the ATPase domain. The mutant Brg1 protein is stable, assembles into SWI/SNF-re...

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تاریخ انتشار 2017